Search results for "maladie cardiovasculaire"
showing 4 items of 4 documents
Low level activity thresholds for changes in NMR biomarkers and genes in high risk subjects for type 2 diabetes
2017
AbstractOur objectives were to determine if there are quantitative associations between amounts and intensities of physical activities (PA) on NMR biomarkers and changes in skeletal muscle gene expressions in subjects with high risk for type 2 diabetes (T2D) performing a 3-month PA intervention. We found that PA was associated with beneficial biomarker changes in a factor containing several VLDL and HDL subclasses and lipids in principal component analysis (P = <0.01). Division of PA into quartiles demonstrated significant changes in NMR biomarkers in the 2nd - 4th quartiles compared to the 1st quartile representing PA of less than 2850 daily steps (P = 0.0036). Mediation analysis of PA-…
Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus
2017
IF 3.566; International audience; The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus, PSA is involved in many aspects of energy balance including food intake, osmoregulation, circadian rhythm, and sleep. In this work, we investigated the role of hypothalamic PSA in the regulation of plasma cholesterol levels and distribution. We report that HFD consumption in mice rapidly increased plasma cholesterol, including VLDL, LDL, and HDL-cholesterol. Although plasma VLDL-cholesterol was normalized withi…
Retinal vascular network: description in elderly and pathological process
2020
For more than 10 years, description of the retinal microvascular network has benefited from the development of new imaging techniques. Automatic retinal images analysis software, as well as OCT angiography, are able to highlight subtle and early changes in the retinal vascular network. In addition, these software allow to obtain a large amount of quantitative microvascular parameters which improve the characterization of retinal vascularization. The challenge of current research is to demonstrate the association between these microvascular modifications, systemic vascular aging process and cerebral and cardiovascular disease. Indeed, a physiopathological continuum exists between retinal mic…
Stress au travail et santé : situation chez les indépendants
2011
Dans de nombreux secteurs d’activité, le stress au travail est considéré comme faisant partie des risques pour la santé auxquels peuvent être confrontés les travailleurs salariés et non-salariés ou indépendants. [br/] Le terme de "stress" peut avoir plusieurs définitions en fonction des disciplines médicales, biologiques, médico-sociales, des sciences humaines et sociales qui y font référence. Quelle que soit l’approche disciplinaire, le stress peut être considéré comme un élément d’un processus complexe, à la fois biologique, psychologique et social en réponse à une situation aversive.[br/] Le régime social des indépendants (RSI), qui assure la couverture maladie et de retraite des artisan…